Fig. 4: Altered gene expression predicts regional anatomical change across patients.
From: Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
a Schematic outlining the analytic approach to interrelating cortical MS changes from MRI and DS gene expression from LCLs in +X patients. b (left) Regional loadings for principal component of shared variance between MS change in brain and DS gene expression in LCLs. (middle) Regional MS change in +X patients compared to controls (from Fig. 1a). Spatial similarity between these maps indicates that +X patients with greater dysregulation of DS genes in blood show a more pronounced manifestation of the +X MS change map. (right) This spatial similarity is quantitatively strong (r = 0.59) and statistically significant (PSPIN < 0.0001).
