Fig. 5: Practical synthetic applications of cobalt-catalyzed asymmetric hydrogenation.
From: Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
a Synthesis of (S)-Equol intermediate via cobalt-catalyzed hydrogenation. b Synthesis of Rupinnavir intermediate. c Synthesis of Sacubitril intermediate. d Asymmetric synthesis of Naproxen. e Asymmetric synthesis of Ibuprofen. f Gram-scale asymmetric hydrogenation of artemisinic acid 5.
