Fig. 7: Astrocytic Ca2+ signaling during sleep is dependent on the IP3 pathway. | Nature Communications

Fig. 7: Astrocytic Ca2+ signaling during sleep is dependent on the IP3 pathway.

From: Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep

Fig. 7

a Representative x-y-t rendering of ROAs during NREM, IS, and REM sleep in WT and Itpr2−/− mice. b–e Mean ROA frequency expressed as number of ROAs per 100 μm2 per minute (b), the percentage of active voxels (x-y-t) (c), ROA duration (s) (d), and ROA area (μm2) (e) during NREM, IS, and REM sleep in WT and Itpr2−/− mice. Data represented as estimates ± SE and p-values (two-sided test, no adjustment for multiple comparisons) derived from linear mixed effects models statistics, n = 6 mice, 196 trails for WT, n = 6 mice, 100 trials for Itpr2−/−. For details on statistical analyses, see “Methods.” See also Supplementary Fig. 14.

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