Fig. 2: Non-CpG methylation by DNMT3A and DNMT3B. | Nature Communications

Fig. 2: Non-CpG methylation by DNMT3A and DNMT3B.

From: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

Fig. 2

a, b CpG and non-CpG methylation of mDNMT3A a and mDNMT3B b averaged for the different +1 flanking base pairs. The cytosine-containing dinucleotides are displayed on the horizontal axis and +1 base is shown in the different bars, respectively. Data are mean of two replicates a or mean ± SD of 4 replicates b. c, d eRRBS analysis of CpG and non-CpG methylation in TKO cells introduced by hDNMT3A c and hDNMT3B d averaged for the different +1 flanking base pairs (depth of reads >10). The cytosine-containing dinucleotides are displayed on the horizontal axis and +1 base is shown in the different bars. Source data are provided as a Source Data file.

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