Fig. 1: Postnatal dynamics of the intestinal microbiota composition.
From: Bile acids drive the newborn’s gut microbiota maturation
a Image illustrating the study outline; one mouse from each one litter was analyzed for each individual time point (PND). b and c Richness (observed species) of the small intestinal (b) and colonic (c) microbiota exhibiting a gradual increase with age (n = 5 per PND for all subsequent analyses, mean and SD, p < 0.0001, linear regression R2 = 0.7702 and p < 0.0001, linear regression R2 = 0.7281, respectively). d Principal Coordinate Analysis (PCoA) based on Bray-Curtis dissimilarity indicating a gradual shift in microbial community structure along PC2 during the neonatal period PND1-PND14 and distinct structures for the small intestine and colon along PC2 at PND21-56 (p < 0.001, two-sided, Permanova for age and p < 0.01 two-sided, Permanova for tissue); Squares and solid line: colon (C); triangles and dashed line: small intestine (SI). e, f Relative abundances of the 10 most abundant genera listed in f between PND1-56 for the small intestine (e) and colon (f). Source data are provided as a Source Data file.
