Fig. 3: Enterohepatic cooperation in the maturation of the microbiota.
From: Bile acids drive the newborn’s gut microbiota maturation
a Relative abundance of the predicted bacterial bile salt hydrolyses (KO1442) in the small intestinal microbiota (n = 5 per group, means connected and replicates). b Total concentration [µmol / gram] of primary (blue) and secondary (red) bile acids (n = 3 for PND1 and n = 5 for PND7-56, means connected and replicates). c, d Coefficients of the regularized canonical correlation analyses (rCCA) indicating the relationship between primary bile acids and small intestinal OTUs on the first component (c) and second component (d) (selected bile acids are highlighted in red). e Correlation heatmap based on the coefficients of the rCCA between hepatic primary bile acid concentrations and relative abundances of small intestinal OTUs indicated a strong positive effect (red) of GCA and UDCA on many Lactobacillus OTUs. Source data are provided as a Source Data file.
