Fig. 4: HNF4A, GR, STAT3, and STAT5 binding at enhancer elements.
From: Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury
a Genome-wide coverage plots at all, SHARED, IRI-decreased and IRI-increased enhancers. The coverage for HNF4A and GR decreased in SHARED and IRI-decreased enhancer group after IRI. In contrast, STAT3 shows increased coverage at IRI-increased enhancers. STAT5 peak height at enhancer elements is unchanged after kidney injury. b Representative examples of transcription factor binding at enhancer sites in kidney epithelia cells. The Slc34a1 and Junb genomic locus are shown for HNF4A, GR, STAT3, and STAT5 binding together with H3K4me3 and H3K27ac in the SHAM (left) and IRI (right) condition. Enhancer elements are indicated by gray bars.
