Fig. 2: Structure of human TMA16.
From: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export
a Cryo-EM maps of states pre-A and state A (Gaussian filtered with sDev of 1.058 Å), with TMA16, 5S rRNA, part of H25ES7, H39 and H42 color-coded. b Secondary structural elements and the atomic model of human TMA16. c Zoom-in view showing the surrounding of TMA16. Two PTC-located assembly factors are also shown (NMD3 and GTPBP4). The three boxed regions are further detailed in panels d, g and h. d Comparison of H39 in state A (orange) and state B (gray). e Interactions between the N-terminus of TMA16 and H39 (immature conformation) in state A. f R22 of TMA16 interacts with G1864 of H39. g, H18 of TMA16 stacks with the base of A1867 of H39. h, Interactions between the helix 1 of TMA16 and the 5S rRNA in state A. i, Interactions between the H2-H3 loop region of TMA16 and H42 of the 28S rRNA.
