Fig. 5: Claudin-low subgroups show distinct activated biological pathways. | Nature Communications

Fig. 5: Claudin-low subgroups show distinct activated biological pathways.

From: Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution

Fig. 5

Heatmaps of ssGSEA scores for each MSigDB hallmark gene-set signature (median by molecular subtype) for a METABRIC and b TCGA datasets. ASCAT median purity score of each subtype is indicated on the top heat map annotation. Claudin-low tumors cluster together in a specific branch of the dendrogram downstream distinguishing CL1 from CL2/CL3 tumors. Hallmark gene-set cluster in three main groups of pathways related to luminal, basal, and claudin-low tumors. ASCAT: allele-specific copy number analysis of tumors; MSigDB: molecular signature database; ssGSEA: single-sample GSEA. Clustering method: Complete; distance: Euclidean.

Back to article page