Fig. 5: Proposed model for choline transport and Slc44a2 regulation of platelet activation. | Nature Communications

Fig. 5: Proposed model for choline transport and Slc44a2 regulation of platelet activation.

From: The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

Fig. 5

We propose that Slc44a2 transports choline into mitochondria, where it is metabolized and regulates the production of ATP and release of ROS. ATP is released from platelets and hydrolyzed to ADP which acts upon platelet purinergic receptors and drives further platelet activation.

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