Fig. 1: Healthspan, parental lifespan, and longevity are highly genetically correlated.
From: Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
a Pairwise genetic correlation between human ageing studies. b Genetic correlations of age-stratified parental lifespan against healthspan and longevity. c Genetic correlations (rg) of ageing traits with traits related to development, behaviour, and disease. In bold are traits with heterogeneous correlations (Phet < 0.05). Displayed here are 17 traits which have at least one significant (FDR < 5%) genetic correlation with healthspan, parental lifespan, or longevity, out of the 27 traits tested. The 17 traits are clustered by Euclidean distance based on their genetic correlation with all tested traits (30 in total). See Supplementary Data 1 for a full list of correlations and Supplementary Table 1 for the number of SNPs used to calculate each pairwise correlation. Blank squares represent correlations which did not pass multiple testing correction. Note that fewer correlations with longevity will pass this threshold due to the smaller sample size of this GWAS. Error bars represent 95% confidence intervals of the correlation estimates. COPD: chronic obstructive pulmonary disease.
