Fig. 1: Performance of commercial assays for the detection of SARS-CoV-2-specific antibodies. | Nature Communications

Fig. 1: Performance of commercial assays for the detection of SARS-CoV-2-specific antibodies.

From: An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment

Fig. 1

Correlation of SARS-CoV-2 neutralizing antibody titers tested by a plaque reduction neutralization assay (PRNT50) to antibodies measured by selected assays. (a) Wantai Ig total ELISA, (b) Wantai IgM ELISA, (c) Euroimmun IgG ELISA, (d) Euroimmun IgA ELISA, (e)  DiaSorin Liaison XL IgG chemiluminescence immunoassay, (f) Cellex IgM/IgG, (g) InTec IgM/IgG, (h) Orient gene/Healgen IgM/IgG. Turquoise dots indicate patient specimen collected ≤7 days post onset of  symptoms  (dps), magenta  dots indicate samples collected from 8–14 dps, gray dots indicate specimen collected more than 14 dps. Dotted lines indicate the cut-off for positivity of each assay, as indicated by the manufacturer: Wantai ELISAs, OD ratio > 1; Euroimmun ELISAs, OD ratio > 1.1; DiaSorin Liaison IgG >15 AU/ml. OD: optical density, AU: arbitrary units, r: correlation coefficient. (i) Percentages of specificities and sensitivities of the various platforms tested. The arrow bar indicates the upper and lower limit of the 95% CI. Source data are provided as a Source Data file.

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