Fig. 3: The enhancer physically interacts with lncRNA promoters. | Nature Communications

Fig. 3: The enhancer physically interacts with lncRNA promoters.

From: A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer

Fig. 3

a The TAD structure overlaid with gene annotations at the 8q24 region as seen from the HiC data in LNCaP cells. b Plots show 4C on the enhancer viewpoint using 4C-ker pipeline. c 4C plots from PCAT1 promoter viewpoint and d long-range interaction from 4C at PVT1 viewpoint, note the interactions marked by arrows. Tracks below the 4C plots in b–d show the ChIP-seq signal of AR and H3K27ac at the regions. e Comparative HiC in LNCaP and T47D showing the differential interactions at the 8q24 locus in the two cell lines. The red pixels show higher interactions in LNCaP and the blue ones show higher interactions in T47D, the heatmap is overlaid with gene annotations and TADs boundaries. 4C data are provided as source data file.

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