Fig. 2: Interactions of the endonuclease with the other polymerase domains.

a Overview of the endonuclease interactions with the other polymerase domains. LACV-L orientation is the same as in Fig. 1c. Secondary structures and residues interacting with different parts of the endonuclease are shown in non-transparent and labeled. The endonuclease is colored from dark green on the N-terminus to light green on the C-terminus. The core lobe, fingers, thumb ring, lid, mid-thumb ring linker, mid, CBD are colored as in Fig. 1a. b Close-up view of the endonuclease N-terminus. Transparent surface of the polymerase is shown. The secondary structures of the core lobe and thumb ring domains that interact with the N-terminal tag are displayed, labeled and colored as in a. The N-terminal tag is represented as a dark green dotted line. c Close-up view of the interactions between the endonuclease and the following LACV-L domains: fingers, palm and CBD. The endonuclease is displayed as a transparent surface and colored as in a. d Close-up view of the interactions between the endonuclease and the following LACV-L domains: thumb ring, lid, mid-thumb ring linker and mid. The endonuclease is displayed as in c. The secondary structures are labeled and the N-terminal tag is represented as a dark green dotted line.