Fig. 2: Retrosynthetic analysis of (+)-caldaphnidine J.
From: Asymmetric total synthesis of yuzurimine-type Daphniphyllum alkaloid (+)-caldaphnidine J
The key disconnections include a Ni(0)-mediated reductive coupling reaction, a ketene dithioacetal Prins reaction, an enyne acetal Nazarov carbocyclization and a ring cleavage strategy.
