Fig. 1: brc-1 and brd-1-deficient nematodes accumulate mutations in their genomes.

a Size and junction representation of deletions that were obtained in wild-type (n = 4), brc-1 (n = 6) and brd-1 (n = 3) mutant animals. Deletions without homology are marked in grey, deletions with homology are marked in blue. Increasing homology size is depicted by increased colour intensity. Deletions with insertions are marked in red. The median deletion sizes are indicated by horizontal lines. b Size and junction representation of tandem duplication (TD) that were obtained in wild-type, brc-1 and brd-1 mutant animals. TDs without homology are shown in grey, TDs with homology are marked in blue. Increasing homology size is depicted by increased colour intensity. TDs with insertions are marked in red. The median TD sizes are indicated by horizontal lines. c Quantification of the average rate of deletions per generation in animals of different genotypes. The rate is defined as the number of deletions divided by the number of propagated generations per animal. The rate per strain is represented in blue dots. Two-tailed t-tests were used to determine statistical significance (*P < 0.05, **P < 0.01). d Quantification of the average rate of TDs per generation in animals of different genotypes. The rate is defined as the number of TDs divided by the number of propagated generations per animal. The rate per strain is represented in blue dots. Two-tailed t-tests were used to determine statistical significance (*P < 0.05, **P < 0.01). e A representation of base substitution type and the average rate of base substitutions per generation in animals of different genotypes. The different types of base substitutions are labelled with different colours. The rate is defined as the number of base substitutions divided by the number of propagated generations per animal. The rate per strain is represented in blue dots. Two-tailed t-tests were used to determine statistical significance (*P < 0.05, **P < 0.01). Error bars represent SEM. Wild type: n = 4 of 60 generations, brc-1: n = 6 of 58 generations, brd-1: n = 3 of 50 generations.