Fig. 4: Worms lacking BRC-1 and POLQ-1 are hypersensitive to ionising irradiation (IR).
From: BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining
Wild type (dark blue), lig-4 (blue), polq-1 (light blue), brc-1 (red), brc-1 lig-4 (grey) and brc-1 polq-1 (dark grey) L4 larvae were exposed to 0, 20, 40 or 60 Gy IR (n = 3, wild type and brc-1: n = 4). Three days after irradiation, the numbers of alive offspring versus unviable eggs were quantified. The average survival in each experiment is represented in blue dots. Statistical analysis shows significant differential loss of viability between brc-1 polq-1 and brc-1 animals (two-tailed t-tests vs. brc-1 mutant *P < 0.05; **P < 0.01, ***P < 0.001). Error bars represent SEM.
