Fig. 5: Model in BRC-1/BRD-1-deficient cells, inefficient resection leads to impaired strand invasion.
From: BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining
When strand invasion cannot occur, break ends are joined by polymerase theta. When strand invasion does occur, reannealing of the extended invaded strand can be hindered by insufficient resection of the receiving strand, again leading to direct end-joining by polymerase theta. When both break ends are sufficiently resected, error-free repair can take place, similar to repair in wild-type cells.
