Fig. 2: DLBCL and Eµ-myc lymphoma share predictive genes sets.
From: H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
a Heatmap of 39 primary Eµ-myc lymphomas based on genes being commonly differentially expressed in non-progressing vs. relapsing DLBCL patients. b Same as in (a), but for 470 DLBCL patients (GSE31312). Eµ-myc lymphomas and DLBCL patients were separated into two clusters by hierarchical clustering using Pearson’s distance correlation and complete linkage. Because of little very high and very low z-scores, they were restricted to the interval [−5,5] after hierarchical clustering for presentation purposes only. c Tumor-free survival of CTX-treated Eµ-myc lymphomas stratified by two hierarchical clusters (ncluster 1 = 34, ncluster 2 = 42) as shown in (a). Two mice per lymphoma were used. d Progression-free and overall survival of R-CHOP-treated DLBCL patients stratified by the two hierarchical clusters as shown in (b) (ncluster 1 = 297, ncluster 2 = 173).
