Fig. 1: Influence of half-life on peak to trough in steady state in dogs with once daily dosing.
From: Molecular engineering of safe and efficacious oral basal insulin
The simulations were based on data for OI338 tested in dogs and the PK profiles were normalized to the area-under-the-curve (AUC) for a 24-h period. Absorption and volume of distribution was kept constant and clearance was changed dependent of the elimination half-life.
