Fig. 4: Identification of fibroblast clusters and their expression features.

a tSNE plot of 31,654 fibroblasts, colored by cluster. b Expression-based pathway activities scored by GSVA per fibroblast cluster. c Stacked histogram showing fibroblasts composition across the 6 pathological stages. d Line chart displaying changing trend of proportion of the four selected clusters across the six pathological stages. e Bubble plot showing scale normalized expression of representative genes involved in cytokine secretion, complement activity, and antigen presentation. Size of dots represents percentage of cells expressing corresponding genes in the cluster.