Fig. 5: Characterization of multiple changes in T cell subtypes. | Nature Communications

Fig. 5: Characterization of multiple changes in T cell subtypes.

From: Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer

Fig. 5

a–c tSNE plots of 8032 T cells, 3812 CD8+ T cells, and 2635 CD4+ T cells. Color indicates cluster. d Histogram showing CD8+ T cell composition across the six pathological stages. Color indicates cluster designated in b. e Violin plots of marker gene expression among CD8+ T cell clusters. f Histogram showing CD4+ T cell composition across the six pathological stages. Color indicates cluster designated in c. g Line chart displaying changing trend of the four selected cluster proportions across the six pathological stages. h Bubble plot showing scale normalized expression of three representative genes involved in type 1, 2, and 3 immune response, respectively, from stage INF to stage ICA. Size of dots represents percentage of cells expressing corresponding genes in the stage.

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