Fig. 7: Integration of non-uniform conjunctive cell inputs accounts for directional modulation.
a Rate map and head direction polar histograms of conjunctive cell spike firing probabilities (with the peak probability listed above) were convolved with the head direction and position of experimentally tracked mice to generate conjunctive cell firing fields (peak firing rates indicated above). Firing times of the simulated conjunctive cells were used to trigger synaptic input to a compartmental model of a stellate cell. b Representative rate-coded firing fields and head direction histograms from a simulation with five conjunctive cell inputs. c Directionally binned firing rate for selected fields colour coded according to the accompanying rate map. Grey lines are the corresponding shuffled distributions. Asterisks indicate bins in which the observed data differs significantly from the shuffled data (p < 0.05, two-tailed p value calculated from the shuffled distribution and corrected for multiple comparisons with the Benjamini–Hochberg procedure). d Comparison of conjunctive cell input models with experimental data, showing significant bins per field (left), and proportion of directional fields (right). The number of significant bins per field in the high conductance (high gex) non-uniform model was greater than for the rat data (p = 5.7 × 10−9, one-way ANOVA with Games–Howell test) but did not differ significantly from the mouse data (p = 0.299), whereas the low conductance (low gex) non-uniform model had fewer significant fields than the mouse data (p = 6.1 × 10−6) but not did not differ significantly from the rat data (p = 0.172). Both high- and low-conductance uniform models had fewer significant bins per field than the mouse data (p = 7.1 × 10−8 and p = 7.1 × 10−9, respectively) and rat data (p = 1.8 × 10−4 and p = 1.3 × 10−4, respectively).
