Fig. 1: Deep enzymology methylation data of the hemimethylated 349 bp substrate. | Nature Communications

Fig. 1: Deep enzymology methylation data of the hemimethylated 349 bp substrate.

From: DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation

Fig. 1

a Time course of the overall methylation levels. b Time dependence of the methylation profile of the 44 CpG sites. c Enrichment and depletion of individual bases at different flanking positions in the most preferred and most disfavored CpG sites in (b). d Single molecule analysis showing the fraction of DNA molecules with different number of methylated CpG sites. The bars in (a), (b), and (d) display the average of two independent experiments. Source data are provided as a Source Data file.

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