Fig. 2: Fitting of the experimental methylation data reveals a processive methylation mechanism. | Nature Communications

Fig. 2: Fitting of the experimental methylation data reveals a processive methylation mechanism.

From: DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation

Fig. 2

Schematic drawing of the kinetics models of the DNA methylation mechanism of DNMT1 used for fitting of experimental data. We used a purely distributive model (Model 1, a) or a mixed model including distributive and processive methylation (Model 2, b). The corresponding reactions are indicated below the schemes. Comparison of the experimental data (colored areas) and best fit (colored lines) for the distributive (c) and mixed (d) models. Model parameters after fitting for the distributive (e) and mixed (f) models. AIC, Akaike Information Criterion.

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