Fig. 7: Comparison of DNMT1 flanking sequence preferences with genomic DNA methylation. | Nature Communications

Fig. 7: Comparison of DNMT1 flanking sequence preferences with genomic DNA methylation.

From: DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation

Fig. 7

a Correlation of the DNMT1 NNCGNN flanking sequence preferences (Activity DNMT1) with average genome-wide methylation levels of CpG sites in NNCGNN flanking contexts (Genome). Genomic methylation data were determined by whole genome bisulfite analysis in wild type mouse ES cells (wt), DNMT1 knock-out ES cells (1KO), DNMT3A/DNMT3B double knock-out ES cells (DKO) and DNMT1/DNMT3A/DNMT3B triple knock-out ES cells (TKO)42. The image shows the average methylation levels of individual NNCGNN sites as heatmaps. b Pearson correlation factors of the NNCGNN genome methylation patterns (Genome) of the different mouse ES cell lines with the flanking sequence preferences (Activity) of DNMT1, DNMT3A and DNMT3B (Fig. 3b) and an average of DNMT3A and DNMT3B (DNMT3). DNMT3A and 3B flanking preferences were taken from Gao et al.25.

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