Fig. 2: T3 transection SCI causes the chronic accumulation of hematopoietic stem cells and differentiated progenitors. | Nature Communications

Fig. 2: T3 transection SCI causes the chronic accumulation of hematopoietic stem cells and differentiated progenitors.

From: Spinal cord injury causes chronic bone marrow failure

Fig. 2

a Hematopoietic hierarchy of HSPCs and their cell surface markers. Total number of bone marrow cells (b), LSKs (c), long-term HSCs (d), short-term HSCs (e), multipotent progenitors 2–4 (f–h), and granulocyte–monocyte progenitors (i) at 28 dpi. j Mean fluorescence intensity of yH2AX expression (i.e. replication stress) within c-Kit+ HSPCs at 28 dpi. All data are mean ± SEM, two-sample t-test; n = 9 and 10/group (b–i), n = 5 and 4/group (j). Dotted lines represent average data from naïve mice. dpi days post-injury, Lam laminectomy (sham injury). Source data are provided as a Source Data file.

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