Fig. 3: T3 transection SCI prevents acute HSPC mobilization into blood and trafficking to the spleen at 3 dpi. | Nature Communications

Fig. 3: T3 transection SCI prevents acute HSPC mobilization into blood and trafficking to the spleen at 3 dpi.

From: Spinal cord injury causes chronic bone marrow failure

Fig. 3

a–f Outcomes in female mice at 3 dpi. a Total numbers of CFCs per mL of whole blood. b Total numbers of CFCs per spleen. c Spleen weight and number splenocytes (% of Lam). d, e Total numbers of (d) LSK and (e) c-Kit+ cells in the spleen. f Proportion of proliferating c-Kit+ cells (S–G2–M phase) in the spleen. g–i Identical parameters as measured in a–c in male mice at 3 dpi. All data are mean ± SEM, two-sample t-test; n = 15/group in a; n = 10/group in b–d (15/group spleen weight); n = 6/group in e, f; n = 4 and 5/group g–i (8 and 9/group spleen weight). Dotted lines represent average data from naïve mice. dpi days post-injury, Lam laminectomy (sham injury), CFCs colony forming cells. Source data are provided as a Source Data file.

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