Fig. 8: Prognostic biomarkers in centenarians stratified by the age at death.

Spearman’s correlation coefficients of the relationships between prognostic biomarkers identified in Fig. 4 and albumin, and age at enrollment were calculated within decedent centenarian categories: decedent centenarians (died between 100–104 years, blue line), decedent semi-supercentenarians (died between 105–109 years, green line), and decedent supercentenarians (died at ≥110 years, red line). The shaded area represents the 95% confidence interval of the correlation line. All the biomarkers were assessed at the time of enrollment. Population sizes for the five biomarkers differ due to variation in the bio-banking of samples. NT-proBNP indicates N-terminal pro-brain natriuretic peptide. *p < 0.05, **p < 0.01, ***p < 0.001.