Fig. 2: Inhibiting FXIIa of different species. | Nature Communications

Fig. 2: Inhibiting FXIIa of different species.

From: Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Fig. 2

a Inhibition of the intrinsic coagulation pathway in human, mouse, rabbit, and pig plasma ex vivo. The aPTT in the presence of different concentrations of FXII900 is shown. For human and mouse plasma, the aPTT of FXII618 was measured for comparison. All coagulation times were determined in two, four or six independent measurements. Mean values are indicated. Data of individual measurements are shown as dots. b PT in the presence of different concentrations of FXII900 and FXII618 in human plasma (upper panel), and FXII900 in mouse, rabbit, and pig plasma (lower panel). PT was determined in two (human plasma) or three independent measurements (all animal plasmas). Mean values are indicated. Data of individual measurements are shown as dots. For the animal plasmas, means  ± SD is indicated. c Inhibition of recombinant FXIIa (rFXIIa) from different species by FXII618 and FXII900. The inhibition of human FXIIa derived from blood is shown for comparison (data from Fig. 1c). Residual FXIIa activities were determined in two (human, mouse) or three (pig, rabbit) independent measurements. Mean values are indicated. For pig and rabbit FXIIa inhibition, the data are presented as mean ± SD. Source data of a–c are provided as a Source data file.

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