Table 3 Associations showing consistent direction of effect for the methylation–gene expression–prostate cancer risk pathway.
CpG site | Chr | Position | Associated gene | Classification | DNA methylation and prostate cancer risk | DNA methylation and gene expression | Gene expression and prostate cancer risk | |||
|---|---|---|---|---|---|---|---|---|---|---|
OR | P value | Association coefficient | Association P value | OR | P value | |||||
cg20240347 | 1 | 204465584 | MDM4 | Upstream | 0.93 | 2.61 × 10−19 | 0.21 | 1.69 × 10−14 | 0.36 | 1.55 × 10−19 |
cg15199181 | 1 | 205670604 | NUCKS1 | Upstream | 0.94 | 5.10 × 10−9 | −0.08 | 2.18 × 10−3 | 3.20 | 2.81 × 10−8 |
cg14893161 | 1 | 205819251 | PM20D1 | UTR5 | 0.97 | 1.11 × 10−7 | −0.08 | 2.70 × 10−3 | 1.07 | 2.40 × 10−7 |
cg07167872 | 1 | 205819463 | Upstream | 0.97 | 1.47 × 10−7 | −0.08 | 1.83 × 10−3 | |||
cg24503407 | 1 | 205819492 | Upstream | 0.97 | 1.27 × 10−7 | −0.08 | 2.78 × 10−3 | |||
cg07157834 | 1 | 205819609 | Upstream | 0.96 | 1.07 × 10−7 | −0.08 | 2.12 × 10−3 | |||
cg02652597 | 2 | 85811292 | VAMP5 | Upstream | 0.93 | 6.31 × 10−7 | −0.16 | 8.76 × 10−9 | 1.19 | 5.01 × 10−3 |
cg10165864 | 2 | 173419899 | PDK1 | Upstream | 0.89 | 6.02 × 10−14 | −0.14 | 9.34 × 10−8 | 1.86 | 8.81 × 10−12 |
cg16797009 | 2 | 173472347 | Downstream | 0.90 | 2.31 × 10−16 | −0.17 | 3.52 × 10−10 | |||
cg25053018 | 2 | 173477995 | Downstream | 1.19 | 4.47 × 10−20 | 0.11 | 3.10 × 10−5 | |||
cg07128416 | 3 | 113160490 | CFAP44 | Upstream | 1.25 | 9.81 × 10−11 | 0.09 | 6.67 × 10−4 | 1.25 | 7.44 × 10−7 |
cg07054641 | 3 | 113160554 | Upstream | 1.22 | 6.46 × 10−11 | 0.09 | 6.47 × 10−4 | |||
cg20138861 | 3 | 169775992 | GPR160 | Intronic | 1.17 | 3.70 × 10−14 | −0.11 | 5.97 × 10−5 | 0.78 | 2.03 × 10−16 |
cg24064041 | 6 | 30165027 | TRIM26 | Intronic | 0.91 | 3.36 × 10−9 | 0.13 | 8.69 × 10−7 | 0.43 | 1.19 × 10−11 |
cg00266604 | 6 | 30178343 | Intronic | 1.21 | 2.05 × 10−12 | −0.10 | 3.84 × 10−4 | |||
cg12001709 | 6 | 31466798 | MICB | Intronic | 0.96 | 4.25 × 10−8 | 0.10 | 1.73 × 10−4 | 0.94 | 8.86 × 10−4 |
cg13892322 | 6 | 31648564 | LY6G5C | Upstream | 0.88 | 5.48 × 10−7 | −0.12 | 4.42 × 10−6 | 1.06 | 9.52 × 10−5 |
cg22786465 | 6 | 31649502 | Downstream | 1.23 | 7.28 × 10−10 | 0.08 | 2.49 × 10−3 | |||
cg02733847 | 6 | 31649519 | Downstream | 1.27 | 2.76 × 10−7 | 0.11 | 1.05 × 10−4 | |||
cg25769566 | 6 | 31651278 | Downstream | 1.05 | 5.09 × 10−8 | 0.26 | <2.00 × 10−16 | |||
cg24520975 | 6 | 31651362 | Downstream | 1.15 | 6.87 × 10−10 | 0.10 | 2.37 × 10−4 | |||
cg07306190 | 6 | 34760872 | UHRF1BP1 | Intronic | 0.95 | 2.36 × 10−8 | −0.33 | <2.00 × 10−16 | 1.11 | 1.99 × 10−8 |
cg01715842 | 16 | 85045600 | ZDHHC7 | Upstream | 1.05 | 2.95 × 10−7 | −0.09 | 6.68 × 10−4 | 0.80 | 2.52 × 10−3 |
cg01799818 | 17 | 594735 | VPS53 | Intronic | 1.10 | 7.40 × 10−19 | 0.09 | 4.81 × 10−4 | 1.03 | 9.02 × 10−3 |
cg10288850 | 22 | 43539588 | MCAT | Upstream | 2.18 | 6.23 × 10−19 | −0.09 | 8.52 × 10−4 | 0.71 | 2.13 × 10−8 |
