Fig. 2: The fungal-specific MCU is a paralogous distinct phylogenetic clade. | Nature Communications

Fig. 2: The fungal-specific MCU is a paralogous distinct phylogenetic clade.

From: Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Fig. 2

Maximum Likelihood phylogenetic trees of MCU (a) and MICU (b) families. The two families have been expanded through duplication rounds in various independent lineages. Major duplication events are indicated with a red sphere on the relevant tree node. The co-occurrence between the two families is almost perfect, if only the true orthologous sequences are considered. MCUP (fungal-specific MCU paralog) and Aralar (MICU distant homolog) sequences are not co-evolving with MCU and MICU, respectively (see also Methods). In both a and b names and relative positions in the trees of members from Holomycota and few other representative species are shown. The main sub-families (MCU/MCUb and MICU1/2/3) are named after the human/mouse sequences within the phylogenetic clades. The phylogenetic positions of MCUs or MCUPs from published structural data are shown in black circles, and the numbers refer to the publication reference. The number of bacterial sequences included in the tree is indicated in brackets. The raw phylogenetic trees in newick format are provided in Supplementary Data 2.

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