Fig. 2: Structural models of bound forms of MDDEF.
From: Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase
a Structural model of MDDEF-MVAPP. The β10-α4 loop is indicated by a black arrow. b SA-ligand-omit map of MVAPP of MDDEF-MVAPP. The map is presented at a sigma level of three (3σ). MVAPP and the interacting residues in the active site of MDDEF are shown as stick models. c Structural model of MDDEF-MVAPP-AMPPCP-Mg2+. The β10-α4 loop and the phosphate-binding loop are indicated by black arrows. d SA-omit map (3σ) of ligands of MDDEF-MVAPP-AMPPCP-Mg2+. e Structural model of the MDDEF-MVAPP-ADPBeF3-Mg2+. The β10-α4 loop and the phosphate-binding loop are indicated by black arrows. f SA-omit map (3σ) of ligands in MDDEF-MVAPP-ADPBeF3-Mg2+. Ligand-binding sites in a, c, and e are indicated by dashed lines.
