Fig. 5: NGFRhi melanoma fractions show immune exclusion in patients.
From: Reversal of pre-existing NGFR-driven tumor and immune therapy resistance
a Examples of two melanomas from patients showing either high or low NGFR expression, and the corresponding CD3 and CD8 stainings for the same regions. Scale bars indicate 50 μm. Quantification in b, c. b, c CD3 and CD8 scores for NGFRneg vs. NGFRpos samples. Only tumor-infiltrating lymphocytes were scored and compared with the relative abundance of tumor cells. Error bars represent S.D. Statistical analysis by Mann–Whitney test; *p < 0.05. d Examples of two melanomas from patients that are heterogeneous for NGFR expression within each sample, and the corresponding CD3 stainings for the same regions (indicated by dotted lines). Scale bars indicate 100 μm. e MCP counter analysis on melanoma cohort of TCGA divided in top and bottom 25% NGFR-expressing tumors. Gene sets for “T cells” and “cytotoxic lymphocytes” are plotted. Error bars represent S.D. Statistical analysis by unpaired t-test. Source data are provided as a Source Data file.
