Fig. 5: Improvement of SECH treatment by inclusion of JQ1.
From: Clearance of HIV infection by selective elimination of host cells capable of producing HIV
a Viral RNA levels in one set of HIV-1-infected Hu-HSC mice (Supplementary Table 3) orally treated by SECH with (black symbols) or without JQ1 (red symbols) for a total of 35 cycles (ART, n = 5 mice; SECH, n = 10 mice; SECH + JQ1, n = 13 mice). The dash line indicates detection limit. b Viral titer in the blood before and after withdrawal of the treatments. (SECH, n = 10 mice; SECH + JQ1, n = 13 mice). No JQ1 vs. JQ1, p = 0.0407 (Mann–Whitney test). c Measuring infectious HIV-1 from spleen and bone marrow cells of HIV-1-infected Hu-HSC mice by TZA. Biological samples from each mouse were measured in three technical replicates. Data are presented as mean ± SD (ART, n = 5 mice; SECH, n = 10 mice; SECH + JQ1, n = 13 mice). ND, not detectable. d hmVOA for spleen and bone marrow cells from mice in c (SECH, n = 7 mice; SECH + JQ1, n = 13 mice). Source data are provided as a Source Data file.
