Fig. 5: Proton translocation and the rotation of Vo domain.
From: Cryo-EM structures of intact V-ATPase from bovine brain
a Overall structure showing the connection between subunit d and c-ring. b The structural elements of subunit a1 with subunit H, e2, and f. The transmembrane helices of a1 have been labeled. c Structural comparison with auto-inhibitory yeast Vo domain (pdb: 6O7T). d The putative proton-translocation mechanism. The residues for the proton transfer are shown in sticks. The cryo-EM map of subunit a is shown. e The cytosolic view of Vo showing the rotation of c-ring in two states. The Glu residues for protonation in state 1 are shown in stick.
