Fig. 2: Comparison of SecR and other class B GPCR Gs-coupled active structures.
From: Structure and dynamics of the active Gs-coupled human secretin receptor
Overlay of secretin (dark red) and SecR (dark green) and different class B GPCR subfamilies emphasizing the position of the receptor ECD and location of the far N-terminus of the receptor (highlighted by red circle (a) or red arrows (b–d). a Glucagon (GCG, pink; GCGR dark blue) and GLP-1 receptors (GLP-1, dark pink; ExP5, red; GLP-1R, dark gray). b PTH1 (PTH, pink; PTH1R, light gray) and PAC1 receptors (PACAP38, pale green; PAC1R, light blue). c CRF1 (CRF, dark green; Urocortin (Uro), orange; CRF1R, blue) and CRF2 receptors (Uro, orange; CRF2R, green). d Calcitonin (sCT, orange; CTR, purple) and CGRP (CGRP, coral; CLR, cyan; RAMP1, green) receptors. Helical secondary structure is shown as cylinders; beta sheets are displayed as flattened arrows.
