Fig. 6: Allantoin degradation pathway links to glycaemia in obesity.
From: Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
The allantoin degradation pathway shows stronger negative correlation with 14 amino acid biosynthesis pathways in the obesity cohort compared to the other cohorts. These pathways represent the biosynthesis of six amino acids: a isoleucine (PWY-5103, PWY-3001, BRANCHED-CHAIN-AA-SYN-PWY and ILEUSYN-PWY), b methionine (PWY-6151, PWY-5347, MET-SAM-PWY and HOMOSER-METSYN-PWY), c threonine (THRESYN-PWY and PWY-724), d lysine (PWY-5097 and PWY-2942), e aspartate (PWY0-781) and f homoserine (METSYN-PWY). All six amino acids are involved in the oxaloacetate/aspartate amino acids biosynthesis pathway. Lines with arrows represent metabolic relationships. Lines with a circle represent an inhibitory role in a metabolic pathway. N = 2379 independent samples are involved (NLLD = 1135, N500FG = 450, N300OB = 298, NIBD = 496). The forest plots show co-abundance strength and direction in each cohort, with square dot for the correlation coefficient and bar for the 95% confidence interval.
