Fig. 1: Single-nuclei transcriptomic cell atlas of the adult human cortex and substantia nigra (SN). | Nature Communications

Fig. 1: Single-nuclei transcriptomic cell atlas of the adult human cortex and substantia nigra (SN).

From: A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

Fig. 1

T-distributed stochastic neighbour embedding (t-SNE) plot of gene expression relationships amongst the single-nuclei cells from five individuals in the (a) substantia nigra (SN) (n = 5943) and (b) cortex (n = 10,706). c Violin plots of expression values (log10 TPM values) of enriched cell-type-specific markers for the cell types in the SN (Supplementary Data 3). d Uniform manifold approximation and projection (UMAP) plot of both the cortex and substantia nigra cell types (n = 16,649 cells) showing distinct clustering by cell type. e Correlation heatmaps showing hierarchical clustering of Pearson correlation scores calculated between averaged cell-type subclusters in both regions. The transcriptional correlation is largely explained by cell type and not by the region of origin. DaNs dopaminergic neurons, Ex excitatory neurons, GABA GABAergic neurons, In inhibitory neurons, ODC oligodendrocytes, OPC oligo-precursor cells.

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