Fig. 1: mC-hnRNPA2-LCD forms a reversible hydrogel that contains amyloid-like fibrils displaying the cross-β diffraction pattern.
From: CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid
a Left micro-centrifuge tube holds a homogenous solution of freshly purified mC-hnRNPA2-LCD. A bubble (box) rises to the top of the tube. The right tube contains the hydrogel formed by concentrated mC-hnRNPA2-LCD; the bubble is trapped by the hydrogel. b Hydrogel formed by mC-hnRNPA2-LCD visualized by transmission electron microscopy shows uniform, amyloid-like fibrils. Scale bar: 500 nm. c X-ray diffraction pattern of the hydrogel formed by mC-hnRNPA2-LCD. The two reflections characteristic of amyloid are visible at 4.7 and 10 Å spacings.
