Table 5 Comparative sequence composition of functional and pathogenic amyloid fibril cores.
From: CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid
Gly (%) | Asn+Gln (%) | Tyr+Ser+Thr (%) | Val+Ala+Ile+Leu (%) | |
|---|---|---|---|---|
HnRNPA2-LCD (functional) | 35.1 | 22.8 | 22.8 | 0.0 |
FUS-LCD (functional) | 19.7 | 18.0 | 59.1 | 0.0 |
Tau PHFs (pathogenic) | 12.3 | 8.2 | 15.1 | 24.4 |
Aβ42 (pathogenic) | 14.3 | 4.8 | 7.2 | 35.7 |
