Fig. 4: Early fate-determining genes or modules show gradual intra-module coordination and inter-module repulsion during cell fate selection. | Nature Communications

Fig. 4: Early fate-determining genes or modules show gradual intra-module coordination and inter-module repulsion during cell fate selection.

From: Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates

Fig. 4

a, b For bifurcations 1 and 2, plots in a pseudotime analysis show average local correlations of genes within and between branch-specific modules, with gradual increase in coordination within each module and increasing antagonistic expression between the branch-specific modules. c, d The plots show average local correlations of module genes with branch-specific early gene modules for both bifurcations, in a set of cells with similar developmental time (marked by black dots). The difference between intra- and inter-module correlations, which characterize the extent of the antagonistic expression between the alternate modules, is shown in the upper right corner of the correlation plots, and represented in a graph in (d) as absolute value in Y axis which would reflect the repulsion between modules. e Schematic of binary fate decision in sensory neurons. f Repulsion of gene modules for the two bifurcations peaks at different pseudotime t.

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