Fig. 3: Trauma re-contextualization is hippocampus-dependent.
From: Preventing and treating PTSD-like memory by trauma contextualization
Top panel, scheme illustration of the behavioral procedure: fear conditioning (Day 1), memory tests (Day 2), trauma re-contextualization (ReC) by complete re-exposure to trauma-related cues (i.e. to the tone in the conditioning context; Day 3) in control CORT-injected and CORT-injected mice exposed to dCA1 inhibition during re-exposure, memory tests (Day 4). Bottom, dCA1 inhibition during complete re-exposure to trauma-related cues on Day 3 blocks the curative effects of such re-exposure: compared to their control (PTSD-like) re-exposed with Laser OFF (ReC; n = 6), PTSD-like re-exposed animals with Laser ON (n = 7) still display an abnormal fear response to the tone (repeated measures × laser condition: F2,24 = 6.452; P = 0.0057) together with a low conditioned fear to the context (laser condition: F1,12 = 6.922; P = 0.0219) on Day 4. The blue bar symbolizes the conditioning context; Pre-T: Pre-Tone; Post-T: Post-Tone. Data are presented as mean ± SEM. This experiment was repeated independently once with similar results, see table in the “Animals” section of the “Methods” for detailed sample size. Statistical significance was assessed by repeated measures (three 2 min-blocks) two-sided ANOVA. *P < 0.05; **P < 0.01. ##: block × condition interaction (P < 0.01). Source data are provided as a Source Data file.
