Fig. 1: Classification of phosphatases in C. neoformans and other fungal species.
From: Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans
a Phylogenetic analysis of phosphatases utilized a protein sequence-based alignment in ClustalX2 (Science Foundation Ireland, Dublin, Ireland). These alignment data were used to illustrate the phylogenetic tree through a web-based drawing application (Interactive Tree Of Life, https://itol.embl.de). Red letters represent pathogenicity-related phosphatases in C. neoformans identified from 114 phosphatase gene-deletion mutants that we constructed. b Pie chart indicating the classification and distribution of 139 phosphatases based on phosphatase-related domain, as analysed by using the InterPro Database. c Pie chart indicating the distribution of putative phosphatase genes in the fungal species S. cerevisiae, S. pombe, C. albicans, and U. maydis surveyed and classified using the same strategies as for C. neoformans.
