Fig. 4: Focal 1300-fold enhancement of drug response by AU-FUS compared to systemic levels. | Nature Communications

Fig. 4: Focal 1300-fold enhancement of drug response by AU-FUS compared to systemic levels.

From: Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers

Fig. 4

a LC-HR-MS/MS quantification of muscimol loaded in one dose of AU-FUS treatment. All data is mean ± s.e.m, showing all points. Average = 199.7 ng, n = 9. b Time course of wEPs (negative peak) in vM1 during systemic injection of muscimol (“Sys. musc.”). Following 10 min of baseline, 130 μg of muscimol (~650 times single muscimol-loaded UC-carrier injection dose) is manually injected over 1 min, every 30 min (black arrows). Data is plotted as the moving average (window size = 180 whisker deflections). All data is mean ± s.e.m. n = 16 (4 rats × 4 recording sites). Equivalent inhibition by AU-FUS would occur between 260 and 390 μg systemic injection.

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