Fig. 1: Somatically targeting PV and dendritically targeting SST inhibitory synapses undergo long-term synaptic plasticity. | Nature Communications

Fig. 1: Somatically targeting PV and dendritically targeting SST inhibitory synapses undergo long-term synaptic plasticity.

From: Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Fig. 1

a Immunohistochemistry showing expression of PV (red) and ChR2 (green) in PV-ChR2 mice. Histogram displaying mean ChR2 fluorescence expression levels in different hippocampal layers: stratum oriens (SO), stratum pyramidal (SP), stratum radiatum (SR) and stratum lacunosum moleculare (SLM) (right top), ChR2 expression as a function of distance across hippocampal layers (right bottom) (n = 9 slices from three animals). b Same as (a) but for SST-ChR2 mice. c Schematic and example IPSC traces highlighting the somatic and distal targeting of PV and SST synapses. d Summary of IPSC decay times for PV and SST IPSCs (p = 0.0003, unpaired t-test, two tailed, n = 14 cells). e Summary of IPSC rise times for PV and SST IPSCs (p = 0.0004, unpaired t-test, two tailed, n = 14 cells). f Schematic displaying the recording set up for inhibitory plasticity experiments and the light-induced theta burst (TBS) induction protocol. g TBS induced iLTD at PV synapses (left) average plasticity at control and test pathways (middle) and example traces before and after plasticity (right) (p = 0.015, paired t-test, two tailed, n = 6 cells). h TBS induced iLTP at SST synapses (left) average plasticity at control and test pathways (middle) and example traces before and after plasticity (right) (p = 0.0011, paired t-test, two tailed, n = 5 cells). Data presented as mean values ± SEM. See also Supplementary Figs. 1 and  2.

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