Fig. 2: PV and SST inhibitory synapses undergo spike timing-dependent plasticity. | Nature Communications

Fig. 2: PV and SST inhibitory synapses undergo spike timing-dependent plasticity.

From: Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Fig. 2

a Schematic highlighting the relative spike timing of PV and SST expressing interneurons during theta oscillations in relation to pyramidal neuron spiking (left). The three pairing protocols used for iSTDP experiments representing presynaptic stimulation and postsynaptic action potentials −60 ms pre before post, 0 ms pre and post together and +60 ms post before pre (right). b −60 ms pre before post pairing induced iLTD at PV synapses (left) average plasticity at control and test pathways (middle) and example traces for before and after plasticity (right) (p = 0.0401, paired t-test, two tailed, n = 7 cells). c 0 ms pre and post pairing induced iLTD at PV synapses (left) average plasticity at control and test pathways (middle) and example traces for before and after plasticity (right) (p = 0.0003, paired t-test, two tailed, n = 13 cells). d +60 ms post before pre pairing failed to induce plasticity at PV synapses (left) average plasticity at control and test pathways (middle) and example traces for before and after plasticity (right) (p = 0.1682, paired t-test, two tailed, n = 8 cells). e Summary of the inhibitory STDP window at PV synapses. f Same as (b) but for SST synapses (p = 0.0099, paired t-test, two tailed, n = 6 cells). g Same as (c) but for SST synapses (p = 0.0481, paired t-test, two tailed, n = 11 cells). h Same as (d) but for SST synapses (p = 0.8315, paired t-test, two tailed, n = 7 cells). i Same as (e) but for SST synapses. Data presented as mean values ± SEM. Scale bars (b–d): 200 ms, 100 pA; f–h 200 ms, 50 pA.

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