Fig. 3: PV-iLTD requires activation of T-type VGCCs and calcineurin. | Nature Communications

Fig. 3: PV-iLTD requires activation of T-type VGCCs and calcineurin.

From: Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Fig. 3

a Presynaptic stimulation of PV inputs alone induced no plasticity (p = 0.530, paired t-test, two tailed, n = 6 cells). b Postsynaptic spikes alone failed to induce plasticity at PV synapses (p = 0.208, paired t-test, two tailed, n = 6 cells). c Inclusion of BAPTA in the internal recording solution occludes PV-iLTD upon 0 ms pre and post pairing (p = 0.366, paired t-test, two tailed, n = 6 cells). d L-type calcium channel antagonist nimodipine does not block PV-iLTD upon 0 ms pre and post pairing (p = 0.0036, paired t-test, two tailed, n = 10 cells). e T-type calcium channel antagonist mibefradil occludes PV-iLTD upon 0 ms pre and post pairing (p = 0.959, paired t-test, two tailed, n = 6 cells). f Calcineurin inhibitor, FK506 occludes PV-iLTD upon 0 ms pre and post pairing (p = 0.545, paired t-test, two tailed, n = 7 cells). In panels (a–f), average plasticity in control and test pathways is shown on the right. g Summary histogram displaying the level of plasticity under each experimental condition significance refers to paired t-tests in (a–f). Data presented as mean values ± SEM. See also Supplementary Fig. 3.

Back to article page