Fig. 4: SST-iLTP requires activation of L-type and T-type VGCCs and CAMKII. | Nature Communications

Fig. 4: SST-iLTP requires activation of L-type and T-type VGCCs and CAMKII.

From: Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Fig. 4

a Presynaptic stimulation of SST inputs alone failed to induce plasticity (p = 0.279, paired t-test, two tailed, n = 6 cells). b Postsynaptic spikes alone failed to induce plasticity at SST synapses (p = 0.623, paired t-test, two tailed, n = 7 cells). c Inclusion of BAPTA in the internal recording solution occludes SST-iLTP upon 0 ms pre and post pairing (p = 0.385, paired t-test, two tailed, n = 6 cells). d L-type calcium channel antagonist nimodipine occludes SST-iLTP upon 0 ms pre and post pairing (p = 0.379, paired t-test, two tailed, n = 5 cells). e T-type calcium channel antagonist mibefradil occludes SST-iLTP upon 0 ms pre and post pairing (p = 0.899, paired t-test, two tailed, n = 7 cells). f Calcineurin inhibitor, FK506 fails to block SST-iLTP upon 0 ms pre and post pairing (p = 0.028, paired t-test, two tailed, n = 7 cells). g CAMKII inhibitor KN-62 occludes SST-iLTP upon 0 ms pre and post pairing (p = 0.120, paired t-test, two tailed, n = 7 cells). In panels (a–g), average plasticity in control and test pathways is shown on the right. h Summary histogram displaying the level of plasticity under each experimental condition significance refers to paired t-tests in (a–g). Data presented as mean values ± SEM. See also Supplementary Fig. 4.

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