Fig. 5: PV-iLTD and SST-iLTP mechanisms. | Nature Communications

Fig. 5: PV-iLTD and SST-iLTP mechanisms.

From: Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Fig. 5

a Illustration of PV-iLTD mechanism. Hyperpolarisation by GABAA receptor currents relieves T-type VGCCs from voltage dependent inactivation (de-inactivation). Back-propagating action potentials then activate T-type VGCCs providing an inhibitory synapse-specific source of Ca2+ to activate calcineurin resulting in LTD at PV synapses. b Illustration of SST-iLTP mechanism. Similar to PV-iLTD but requiring activation of T-type and L-type VGCCs that activates CAMKII resulting in LTP at SST synapses.

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